Cervical cancer detection platform based on novel laser processing

Project Description

Within the scope of this project a highly sensitive platform to detect Human Pappliomavirus (HPV), causative agent of about 99.7% of cervical cancer will be developed. The proposed diagnostic platform will be based on laser textured biopolymer as a device substrate, functionalized with nanoparticles produced via Pulsed Laser Ablation in Liquid (PLAL) technique. This on-chip immunoassay will allow rapid detection of the HPV. The novelty of this project lies in the high-quality bio-nanostructures as nano-labels via PLAL designed for ultrasensitive detection of HPV. Two major aspects of this project are: (1) the development of complex nano-labels specifically targeting high risk HPV; (2) improvement in the performance of the developed assay system by increasing their sensitivity and specificity.