Cervical cancer detection platform based on novel laser processing

Project Description

Within the scope of this project a highly sensitive platform to detect Human Pappliomavirus (HPV), causative agent of about 99.7% of cervical cancer will be developed. The proposed diagnostic platform will be based on laser textured biopolymer as a device substrate, functionalized with nanoparticles produced via Pulsed Laser Ablation in Liquid (PLAL) technique. This on-chip immunoassay will allow rapid detection of the HPV. The novelty of this project lies in the high-quality bio-nanostructures as nano-labels via PLAL designed for ultrasensitive detection of HPV. Two major aspects of this project are: (1) the development of complex nano-labels specifically targeting high risk HPV; (2) improvement in the performance of the developed assay system by increasing their sensitivity and specificity.

Internal Collaborators

Dermot Brabazon, Komal Bagga

External Collaborators

Arrows Biomedical GmbH, NASA Aimes Lab, Standford University

Funding Body

Marie Curie Action